Feed Your Curiosity
Welcome imaginative minds!
Come with me on an adventure
that is captivating, creative,
and will leave you curious for more.
Why Sourdough Labs? Because, just as sourdough thrives with time and care, so do the best innovations.
Your playground for knowledge
Discover the wonders of science and innovation, where curiosity knows no bounds. Ignite your curiosity and explore the realm of possibilities. Let your imagination flourish as you delve into the world of new discoveries and endless learning. Join us on a journey that will spark your curiosity and illuminate the remarkable possibilities of science. From the macro-scale to the micro-scale, let us go on a journey through science together.
“Remember to look up at the stars and not down at your feet. Try to make sense of what you see and wonder about what makes the universe exist. Be curious. And however difficult life may seem, there is always something you can do and succeed at. It matters that you don’t just give up.”
FEATURE
Listen up. It all begins with an idea.
A podcast episode based on my doctoral work
The paper explores the selective vulnerability of layer 5a corticostriatal neurons in Huntington's disease (HD). We used a novel technique called serial fluorescence-activated nuclear sorting (sFANS) to isolate and analyze different cell types from the cerebral cortex of HD patients. What we found was surprising, layer 5a neurons, which project to the striatum, are particularly vulnerable in HD, while other deep layer neurons remain relatively resilient. The study also revealed that extensive somatic expansion of the mHTT CAG repeat occurs in both vulnerable and resilient neurons, suggesting that this expansion alone may not be the primary cause of cell death. In addition, our data suggest that altered synaptic function and disruption of corticostriatal connectivity may play a significant role in the selective vulnerability of layer 5a neurons in HD.
This podcast episode was created using NotebookLM.
Pressl, C., Mätlik, K., Kus, L., Darnell, P., Luo, J. D., Paul, M. R., … Heintz, N. (2024). Selective vulnerability of layer 5a corticostriatal neurons in Huntington’s disease. Neuron, 112(6), 924-941.e10. https://doi.org/10.1016/j.neuron.2023.12.009
